Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor

• Takahide Fukuyama,
• Yu Mukai and
• Ilhyong Ryu

Beilstein J. Org. Chem. 2011, 7, 1288–1293, doi:10.3762/bjoc.7.149

• Takahide Fukuyama Yu Mukai Ilhyong Ryu Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan 10.3762/bjoc.7.149 Abstract The Koch–Haaf reaction of adamantanols was successfully carried out in a microflow system at room temperature. By

• : continuous flow system; hastelloy; Koch–Haaf reaction; microreactor; Introduction The recent evolution of microreactor technology has allowed synthetic chemists to use this precisely sophisticated reaction apparatus in place of the well-established glassware batch flask [1][2][3][4][5][6][7][8][9][10

• intermediates carried out in a continuous microflow system [22][23][24]. The Koch–Haaf reaction [25], that is the carbonylation of alcohols or olefins with formic acid in the presence of a strong acid, is an important reaction for the preparation of carboxylic acids, which are widely used in organic synthesis